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Santa Ana National Wildlife Refuge is a 2,088-acre National Wildlife Refuge situated along the banks of the Rio Grande, south of Alamo in the Lower Rio Grande Valley, in Hidalgo County, South Texas. The wildlife refuge was established for the protection of migratory birds in 1943. Its unique location is at the meeting of different climates and habitats: subtropical wetlands, Chihuahuan Desert, Gulf Coast, and Great Plains.

The Basilica of the National Shrine of Our Lady of San Juan del Valle is a Minor Basilica of the Catholic Church located in San Juan, Texas, United States. It is also a National shrine under the direction of the Diocese of Brownsville